A Rule-driven Approach for Defining the Behavior of Negotiating Software Agents

One problem with existing agent-mediated negotiation systems is that they rely on ad hoc, static, non-adaptive, and hardcoded schemes to represent the behaviour of agents. This limitation is probably due to the complexity of the negotiation task itself. Indeed, while negotiating, software (human) agents face tough decisions. These decisions are based not only on the information made available by the negotiation server, but on the behaviour of the other participants in the negotiation process as well. The information and the behaviour in question are constantly changing and highly uncertain. In the first part of the paper, we propose a rule-driven approach to represent, manage and explore negotiation strategies and coordination information. For that, we divide the behaviour of negotiating agents into protocols, strategies and coordination. Among the many advantages of the proposed solution, we can cite the high level of abstraction, the closeness to human understanding, the versatility, and the possibility to modify the agents' behaviour during the negotiation process. To validate our solution, we ran many agent tournaments, and used the rule-driven approach to implement bidding strategies that are common in the English and Dutch auctions. We also implemented simple coordination schemes across several auctions. The ongoing validation work is detailed and discussed in the second part of the paper. Un des inconvénients qu'on retrouve fréquemment dans les systèmes de négociation par agents est qu'ils reposent sur des schémas ad-hoc, non adaptatifs et figés dans le code pour représenter le comportement des agents. Cette limitation est probablement due à la complexité de l'activité de négociation elle-même. En effet, au cours de la négociation, les agents logiciels (humains) ont des décisions difficiles à prendre. Ces décisions ne sont pas seulement basées sur l'information disponible sur le serveur de négociation, mais aussi sur le comportement des autres participants durant le processus de négociation. L'information et le comportement en question changent constamment et sont très incertains. Dans la première partie de l'article, nous proposons une approche à base de règles pour représenter, gérer et explorer les stratégies de négociation ainsi que l'information de coordination. Parmi les nombreux avantages de la solution proposée, on peut citer le haut niveau d'abstraction, la proximité avec la compréhension humaine, la souplesse d'utilisation et la possibilité de modifier le comportement des agents durant le processus de négociation. Pour valider notre solution, nous avons effectué plusieurs tournois entre agents et utilisé l'approche à base de règles pour implémenter des stratégies simples applicables à l'enchère anglaise et à l'enchère hollandaise. Nous avons aussi implémenté des schémas simples de coordination impliquant plusieurs enchères. Le travail de validation, en cours, est détaillé et discuté dans la seconde partie de l'article.e-negotiation, online auction, software agent, negotiation strategy, coordination, rule-based system, rule engine, Négociation électronique, enchères en ligne, agents logiciels, stratégie de négociation, coordination, système à base de règles, moteur de règles

Addressing Dynamism in E-negotiations by Workflow Management Systems

Workflows (Wfs) are a major enabling technology for e-commerce. In our research, a Combined Negotiation (CN) is modeled and enacted using Wf technology. The modeling task captures the sequencing of the individual negotiations as well as the dependencies between them, and the enacting task runs the model. A CN support system (CONSENSUS) is used by the user to perform both tasks. Supporting dynamic modifications to the model during run-time should increase the benefits of our approach. In this paper, we highlight the need for such support by identifying the dynamic aspects that can occur while negotiating the different items of a package (i.e., the CN object). To address these aspects, we experimented using ADEPT, a Wf Management System supporting dynamism. This leads us to discuss the Wf Reference Model of the Wf Management Coalition, and suggest a "dynamic" extension to the current functional areas and architecture. La technologie des Workflows (Wfs) s'est avérée importante pour le commerce électronique. Dans le cadre de notre recherche, une négociation combinée (CN) est modélisée et exécutée utilisant un Wf. La phase de modélisation capture la séquence des différentes négociations ainsi que les dépendances qui existent entre elles. La phase d'exécution quant à elle, permet comme son nom l'indique, d'exécuter le modèle. Un système de support pour les CN (CONSENSUS) est utilisé pour accomplir ces deux tâches. Supporter les modifications dynamiques du modèle lors de l'exécution devrait augmenter les bénéfices de notre approche. Dans cet article, nous mettons l'emphase sur le besoin d'un tel support, ceci en identifiant les aspects dynamiques qui peuvent apparaître lors de la négociation des différents items d'un package (i.e., l'objet de la CN). Nous utilisons ADEPT - un système de gestion de Wf qui supporte le dynamisme - pour étudier ces aspects. Ceci nous mène à discuter le modèle de référence de la Wf Management Coalition, et à proposer une extension "dynamique" à l'architecture actuelle.e-Negotiations, Sourcing, Workflows, Workflow management systems, Dynamism, Négociations électroniques, Approvisionnement, Workflows, Systèmes de gestion de Workflow, Dynamisme

User interface development and software environments : the Chiron-1 system

User interface development systems for software environments have to cope with the broad, extensible and dynamic character of such environments, must support internal and external integration, and should enable various software development strategies. The Chiron-1 system adapts and extends key ideas from current research in user interface development systems to address the particular demands of software environments. Important Chiron-1 concepts are: separation of concerns, dynamism, and open architecture. We discuss the requirements on such user interface development systems, present the Chiron-1 architecture and a scenario of its usage, detail the concepts it embodies, and report on its design and prototype implementation

Compositional design reuse

Object-oriented software development has proven effective for systems development, but the creation of reusable and changeable software architectures is still a challenging task. Design patterns capture the expertise for reusable design solutions, but there is no methodical approach to providing conceptual design building blocks in tangible and composable form. Design components have been suggested to address this problem. We suggest compositional design reuse, which is a combined approach utilizing the ideas of design components and role models. We claim that design expertise in composable form with explicit documentation provides many advantages. It provides alternative views on software systems at a high level of abstraction, and it can help in prohibiting known design flaws as well as design blurring and degradation during subsequent modifications. In this paper, we refine the notion of design components, include role models, and discuss component types as well as design composition.Eje: Ingeniería de softwareRed de Universidades con Carreras en Informática (RedUNCI

Design composition

Object-oriented software development has proven effective for systems development, but the creation of reusable and changeable software architectures is still a challenging task. Design patterns capture the expertise for reusable design solutions, but there is no methodical approach to providing conceptual design building blocks in tangible and composable form. Design components have been suggested to address this problem. We suggest design composition with design components, role models and role constraints. We claim that design expertise in composable form with explicit design constraints and with explicit documentation has many advantages. It provides alternative views on software systems at a high level of abstraction, and it can help in prohibiting known design flaws as well as design blurring and degradation during subsequent modifications. In this paper, we refine the notion of design components, include role models and constraints, and discuss component types as well as design composition.Facultad de Informátic

Reduced splenic uptake on 68Ga-Pentixafor-PET/CT imaging in multiple myeloma - a potential imaging biomarker for disease prognosis

Beyond being a key factor for tumor growth and metastasis in human cancer, C-X-C motif chemokine receptor 4 (CXCR4) is also highly expressed by a number of immune cells, allowing for non-invasive read-out of inflammatory activity. With two recent studies reporting on prognostic implications of the spleen signal in diffusion-weighted magnetic resonance imaging in patients with plasma cell dyscrasias, the aim of this study was to correlate splenic (68)Ga-Pentixafor uptake in multiple myeloma (MM) with clinical parameters and to evaluate its prognostic impact. METHODS: Eighty-seven MM patients underwent molecular imaging with (68)Ga-Pentixafor-PET/CT. Splenic CXCR4 expression was semi-quantitatively assessed by peak standardized uptake values (SUV(peak)) and corresponding spleen-to-bloodpool ratios (TBR) and correlated with clinical and prognostic features as well as survival parameters. RESULTS: (68)Ga-Pentixafor-PET/CT was visually positive in all MM patients with markedly heterogeneous tracer uptake in the spleen. CXCR4 expression determined by (68)Ga-Pentixafor-PET/CT corresponded with advanced disease and was inversely associated with the number of previous treatment lines as compared to controls or untreated smouldering multiple myeloma patients (SUV(peak)Spleen 4.06 ± 1.43 vs. 6.02 ± 1.16 vs. 7.33 ± 1.40; (P5.79 ((P<) 0.001). Multivariate Cox analysis confirmed SUV(peak)Spleen as an independent predictor of survival (HR 0.75;P= 0.009). CONCLUSION: These data suggest that splenic (68)Ga-Pentixafor uptake might provide prognostic information in pre-treated MM patients similar to what was reported for diffusion-weighted magnetic resonance imaging. Further research to elucidate the underlying biologic implications is warranted

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms.

Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings

Theories of schizophrenia: a genetic-inflammatory-vascular synthesis

BACKGROUND: Schizophrenia, a relatively common psychiatric syndrome, affects virtually all brain functions yet has eluded explanation for more than 100 years. Whether by developmental and/or degenerative processes, abnormalities of neurons and their synaptic connections have been the recent focus of attention. However, our inability to fathom the pathophysiology of schizophrenia forces us to challenge our theoretical models and beliefs. A search for a more satisfying model to explain aspects of schizophrenia uncovers clues pointing to genetically mediated CNS microvascular inflammatory disease. DISCUSSION: A vascular component to a theory of schizophrenia posits that the physiologic abnormalities leading to illness involve disruption of the exquisitely precise regulation of the delivery of energy and oxygen required for normal brain function. The theory further proposes that abnormalities of CNS metabolism arise because genetically modulated inflammatory reactions damage the microvascular system of the brain in reaction to environmental agents, including infections, hypoxia, and physical trauma. Damage may accumulate with repeated exposure to triggering agents resulting in exacerbation and deterioration, or healing with their removal. There are clear examples of genetic polymorphisms in inflammatory regulators leading to exaggerated inflammatory responses. There is also ample evidence that inflammatory vascular disease of the brain can lead to psychosis, often waxing and waning, and exhibiting a fluctuating course, as seen in schizophrenia. Disturbances of CNS blood flow have repeatedly been observed in people with schizophrenia using old and new technologies. To account for the myriad of behavioral and other curious findings in schizophrenia such as minor physical anomalies, or reported decreased rates of rheumatoid arthritis and highly visible nail fold capillaries, we would have to evoke a process that is systemic such as the vascular and immune/inflammatory systems. SUMMARY: A vascular-inflammatory theory of schizophrenia brings together environmental and genetic factors in a way that can explain the diversity of symptoms and outcomes observed. If these ideas are confirmed, they would lead in new directions for treatments or preventions by avoiding inducers of inflammation or by way of inflammatory modulating agents, thus preventing exaggerated inflammation and consequent triggering of a psychotic episode in genetically predisposed persons

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms